About THERAHEAL PN
Intended Use | Tissue remodeling, improvements in skin laxity (on face, neck and body) and wound healing |
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Category | Medical Device & Mesotherapy (Cosmetic) |
Ingredients | PN (Polynucleotide) + PDRN (Polydeoxyribonucleotide) High & low molecular weight hyaluronic acids |
Total Amount of HA | 80 mg / 2.5 ml (40 mg/ml H-HA + 40 mg/ml L-HA) |
Injection Site | Dermis and subcutaneous layers |
Volume | 2.5 ml/syringe, 1 syringe/box |
Storage Method | Store between 1 ~ 25 ℃, protect from light, and avoid freezing. |
Effect of THERAHEAL PN
Recommended Area of THERAHEAL PN Treatment
Treatment Technique
1) Face
2) Neck
Number of Uses and Capacity
Precautions After the Procedure
Non-recommended Person
PN (Polynucleotide) &
PDRN (Polydeoxyribonucleotide)
Anti-Aging & Repair
Mechanism of Action
※ The mechanism of action of PN is almost the same as PDRN.
1) Activation of Adenosine A Receptor
Adenosine activates four distinct adenosine receptors indicated as A1, A2A, A2B, and A3, the A2A receptor plays a central role in modulating inflammation, oxygen consumption, ischemia, cell growth, and angiogenesis. PDRN is able to generate active deoxyribonucleotides, nucleosides, and bases exerting their pharmacological effects and activating the A2A receptor, PDRN interacting with the A2A receptor provides a more complete tissue regeneration and wound healing effect.2) DNA Synthesis Salvage Pathway
Cell growth was accompanied by internalization of PDRN-derived nucleotides to offer purine and pyrimidine rings for the “salvage pathway”. In fact, damaged of hypoxic tissue very often cannot undergo to the DNA “de novo” synthesis. Under these conditions, salvage pathways operate to recover bases and nucleosides generated from the breakdown of DNA and RNA. The salvaged bases can then be transformed into nucleotides and reincorporated into DNA. PDRN generates nucleotides and nucleosides that can contribute to DNA formation, offering a faster tissue regeneration and wound healing effect.Efficacy Experiments
※ The mechanism of action of PN is almost the same as PDRN.
1) Anti-Aging
2) Repair
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